<p>The ionospheric Total Electron Content (TEC) provided by the International GNSS Service (IGS), and the Coupled Thermosphere Ionosphere Plasmasphere Electrodynamics (CTIPe) model simulated TEC have been used to investigate the delayed ionospheric response against solar flux and its trend during the years 2011 to 2013. The analysis of the distinct low and mid-latitudes TEC response over 15° E shows a better correlation of observed TEC and the solar radio flux index F10.7 in the Southern Hemisphere compared to the Northern Hemisphere. Thus, a significant hemispheric asymmetry is observed.</p> <p>The ionospheric delay estimated using model simulated TEC is in good agreement with the delay estimated for observed TEC against Solar Dynamics Observatory (SDO) EUV Variability Experiment (EVE) measured flux. The average delay for the observed (modeled) TEC is 17(16) h. The average delay calculated for observed and modeled TEC is 1 and 2 h longer in the Southern Hemisphere compared to the Northern Hemisphere.</p> <p>Furthermore, the observed TEC is compared with the modeled TEC simulated using the SOLAR2000 and EUVAC flux models within CTIPe over Northern and Southern Hemispheric grid points. The analysis suggests that TEC simulated using the SOLAR2000 flux model overestimates the observed TEC, which is not the case when using the EUVAC flux model.</p>